Dr C P Ravikumar

CLONAZEPAM

clonazepam

What is CLONAZEPAM used for?

Epilepsy / Seizure disorders

Panic disorder

Anxiety

Rapid eye movement sleep behavior disorder

Vertigo, acute episodes

Tardive dyskinesia

How is Clonazepam available (Dosage forms)?

Tablets

Liquid or syrup

Extended-release tablets

Dispersible tablets

CLONAZEPAM VS LORAZEPAM

Clonazepam and Lorazepam are both benzodiazepines, but they differ in their duration and uses. Clonazepam has a longer-lasting effect and is often used for anxiety, panic disorders, and seizures. 

Lorazepam works more quickly but has a shorter duration and is commonly used for anxiety and as a pre-surgery sedative. Both can be habit-forming, so they should be used under a doctor’s supervision.

How does Clonazepam act (mechanism of action)?

It works by boosting the effects of a natural calming chemical in the brain called GABA. It helps prevent certain types of seizures (absence seizures) by slowing down nerve signals in the part of the brain that controls movement.

Can I take Clonazepam for sleep?

Clonazepam can help with sleep due to its sedative effects, but it’s not recommended for long-term use due to the risk of dependence. It’s best to consult a doctor for proper guidance and explore other sleep treatment options.

How much time does Clonazepam take to act?

Clonazepam typically starts to take effect within 30 minutes to 1 hour after ingestion. The full therapeutic effects may be experienced within 1 to 2 hours. However, the exact onset of action can vary depending on factors like individual metabolism, dosage, and whether the medication is taken with food. It is important to follow your doctor’s guidance regarding dosage and use.

Why is Clonazepam important for you/your child’s treatment?

It is important that your child takes Clonazepam regularly so that you/your child doesn’t suffer from Seizures or have fewer seizures episodes and other diseases.

Clonazepam controls seizures but doesn’t cure epilepsy and works only while you keep taking it. So do not stop giving Clonazepam all of a sudden, as it may result in having more seizures

What is the ideal time to take Clonazepam?

Twice a day; morning and evening. Ideally, 10-12 hours apart.
For example, anytime between 7 to 8 am and right after 12 hours between 7 to 8 pm. You can adjust the time slot according to your schedule.
However, there are some exceptions when your doctor may advise to give it thrice a day. Please follow your doctor’s instructions in such case.
It should ideally be given at the same time every day to establish a routine as it minimizes the chances of missing a dose.

When should CLONAZEPAM be taken?

Clonazepam should be taken after food.

How should I give/ take the medicine?

Tablets: A whole tablet must be swallowed with a glass of water, juice or milk. You may give it by crushing and mixing it in water/ juice or small serving of yogurt / Curd.

Liquid or syrup: Use an oral syringe or a medicine spoon to measure the adequate amount. You can easily get these from any pharmacy nearby.

Do not use a kitchen teaspoon as it will not give the accurate amount of the drug.

Extended-release tablets and Dispersible tablets: Swallow the whole tablet; do not split, chew, or crush them

What if I miss a dose?

If you miss the dose, it can be taken as soon as you remember within the lapse of 6 hours. If you miss a dose and it’s nearly time for the next one, just take the next dose. If you miss two or more doses, discuss with your doctor.

NEVER GIVE A DOUBLE DOSE OF CLONAZEPAM

If your child vomits out the content within 30 minutes of taking the medicine dosage then you can give the dose again; but if your child vomits after 30 minutes of taking the dose, then do not give it again.

Could this medication have any side effects on my child?

Every medication has both positive and potential negative effects. Fortunately, adverse effects are not common for everyone, but it’s essential to be aware of them. Understanding possible side effects allows us to act quickly and effectively if they occur, ensuring that we can address any concerns promptly while continuing to benefit from the intended effects of medications.

Even though it may be rare, few people sometimes may have serious side effects when taking a drug. Consult your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect

Side effects of Clonazepam

Nervous system: Trouble with coordination, behavior problems, dizziness, feeling sleepy or tired, Confusion, memory issues, trouble concentrating, mood swings

Gastrointestinal: Stomach pain, constipation, less appetite, Indigestion, heartburn

Urinary/Reproductive: Painful periods, frequent urination, or urinary infections, Trouble urinating

Eyes: Blurred vision, Double vision

Muscles: Muscle pain or weakness, Back pain, joint pain

Infections: Flu-like symptoms.

Heart and circulation: Swelling in the legs, low blood pressure, or heart palpitations.

Skin: Rashes, itching, or dry skin.

Very Rare:

Liver and blood: Changes in liver function or low blood cell counts.

Nervous system: Unusual behavior, memory loss, or dependency.

Other Considerations:

Dependence: Clonazepam can cause dependence if used long-term.

Drooling or excess salivation may be noted, usually, it is transient.

If you notice any serious symptoms or unusual changes, let your healthcare provider know right away.

Does Clonazepam cause weight gain?

Clonazepam does not commonly cause weight gain, but it can affect appetite in some people. A small number of patients may experience increased appetite or weight changes while taking this medication. If you notice significant weight gain or changes in appetite, talk to your doctor to discuss possible solutions or adjustments to your treatment.

Can other common medicines be taken during the course of Clonazepam?

Unless your doctor has told you otherwise, you can give your child paracetamol, ibuprofen, antibiotics, and other essential over-the-counter medications.

However, please consult your doctor giving other medicines to your child. These also include herbal or complementary medicines.

Some other medicines used to treat epilepsy may affect the efficacy of Clonazepam or may cause side effects. If you are worried about this or if your child seems to be having more fits, please contact your doctor immediately.

What food to avoid while taking Clonazepam?

When taking clonazepam, there are no specific foods you must avoid, but certain things should be kept in mind to ensure the medication works properly and to reduce the risk of side effects:

Alcohol: Avoid alcohol while taking clonazepam, as it can significantly increase the sedative effects, leading to drowsiness, dizziness, and even respiratory depression. 

Grapefruit: While not a major concern for clonazepam like it is with some other medications, Grapefruit can affect the metabolism of some medications, potentially altering how your body processes clonazepam.

Caffeine: High amounts of caffeine may reduce the calming effects of clonazepam, so it’s wise to limit your intake of coffee, energy drinks, or other sources of caffeine while on this medication.

High-fat meals: Fatty foods can slow down the absorption of medications. While not a major issue with clonazepam, it is still a good idea to avoid excessively greasy or fatty meals that might interfere with the speed at which the medication takes effect.

General Tips:

  • Hydrate well: Drink plenty of water to stay hydrated, as clonazepam can cause dry mouth.
  • Balanced Diet: Maintain a balanced diet to support overall health, as clonazepam may cause dizziness or fatigue that could make it harder to maintain regular eating habits.

Always follow your healthcare provider’s advice regarding diet, especially if they recommend avoiding any specific foods based on your medical history.

PREGNANCY AND LACTATION:

Pregnancy: Clonazepam is generally not recommended during pregnancy unless absolutely necessary. Taking clonazepam, especially in the first trimester, could increase the risk of birth defects. If you are pregnant or planning to conceive, consult your doctor to understand the potential risks and benefits. Your doctor may suggest alternative treatments or carefully monitor your condition if clonazepam is needed.

Breastfeeding: Clonazepam is generally not recommended during breastfeeding. It’s important to consult with your doctor, who can advise you on the safest options for both you and your baby.

Is there any risk if I conceive while taking Clonazepam?

Yes, there may be risks if you become pregnant while taking clonazepam. This medication can potentially harm the baby, especially during the first trimester. 

If you think you might be pregnant or are planning to conceive, talk to your doctor right away. They can discuss the risks and benefits and help you decide on the safest treatment plan for both you and your baby.

Can I stop taking Clonazepam (withdrawal)?

Clonazepam withdrawal can cause symptoms like anxiety, irritability, insomnia, muscle pain, tremors, and in severe cases, seizures. To prevent withdrawal symptoms, gradually taper the dose under a doctor’s guidance.

Never stop clonazepam suddenly.

Where should you store Clonazepam?

Store clonazepam in a cool, dry place at room temperature, away from heat, moisture, and direct sunlight. Store it in its original container with the lid securely fastened.

Make sure to store it out of reach of children and pets to prevent accidental ingestion.

Monitoring Parameters of Clonazepam

  • Complete Blood cell count
  • Depression and behavioral changes 

How to cope with side effects of clonazepam?

  • Drowsiness or Fatigue: Take the medication at bedtime if approved by your doctor.
    Avoid driving or operating machinery until you are used to the medicine.
  • Dizziness: Get up slowly from sitting or lying down to prevent falls.
    Drink plenty of water and avoid dehydration.
  • Memory or Concentration Issues: Use reminders or write down important tasks.
  • Mood Changes or Depression: Let your doctor know if you feel sad, anxious, or have mood swings.
    Seek help right away if you experience thoughts of self-harm.
  • Digestive Problems (Constipation, Stomach Upset): Eat high-fiber foods, drink plenty of water, and stay active.
    If symptoms persist, consult your doctor.
  • Blurred Vision: Avoid activities that require clear vision until the effect wears off.
    If it doesn’t go away, tell your doctor.

If side effects are severe or don’t improve, contact your doctor for advice. They may adjust your dose or suggest alternatives to help you feel better.

SUMMARY

Clonazepam is a medication primarily used to treat anxiety, panic disorders, and seizures. It belongs to the benzodiazepine class and works by calming the brain and nervous system. It can cause side effects like drowsiness, dizziness, and memory issues. It’s important not to stop clonazepam suddenly, as withdrawal symptoms can occur. Always consult a doctor before making any changes to the dosage or discontinuing the medication.

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